Tristan Bitard-Feildel

My name is Tristan and I am a French Postdoc in Münster, Germany, at the Institute for Evolutionary Biology. I am working with Professor Erich Bornberg-Bauer in the Evolutionary Bioinformatic group

Some keywords: Protein Evolution; Protein domain; Python; Evolutionary Biology; Computational Biology

Tristan Bitard-Feildel
Westfälische Wilhelms University (WWU)
Institute for Evolution and Biodiversity
Evolutionary Bioinformatics Group
Hüfferstrasse 1, D-48149 Münster, Germany

Email: tristan [you know what]
Email: t.bitard.feildel [you know what]
Tel.: +49-(0)251-83-21633
Room: 100.19


My main research concerns the evolution of proteins and protein domains. How new proteins arise, where do old proteins come from, and how they evolved are some general questions that I am interested in.

Currently, I develop tools in collaboration with Isabelle Callebaut group's based on the analysis of the hydrophobic pattern of protein sequences. We want to understand what are the physico-chemical properties of recent protein domains and the genomic mechanisms leading to the creation of these new domains.

The evolution of proteins can also be studied in comparative genomic analyses. In Erich's group, we are studying the evolution of proteins and protein domains in Arthropoda/Insecta species. I perform protein domain and protein domain arrangement comparisons taking into account the phylogenetic tree of the species annotated and the functional annotations of the proteins.
Using, for example, Dollo parsimony, I can reconstruct ancestral states and link the presence of major functional innovations with the emergence of new proteins.
The domain and functional annotations, using GO terms, bring understanding on the reuse of protein domains by species to adapt and to evolve new functions.

In a transversal axis, I am working in collaboration with the group of Günther Wagner on the analysis of RNA-seq data combined with protein domain annotations. My research on this topic focus on the detection of the changes in mRNA level expressions associated with the emergence of new protein domains or new protein domain arrangements

Most of my research involves the development of new softwares and new methodologies linked to protein domain. I am particularly interested in projects requiring optimization and/or machine-learning approaches.
I am a Python fanboy and an experienced user of its computational libraries. But when needed I can easily switch to my second and third favorite languages: C and C++. My statistical analyses are either done using Python or the specialized libraries of R/Bioconductor.



  • Tristan Bitard-Feildel, Erich Bornberg-Bauer, Isabelle Callebaut.
    OrphHCA: detection of conserved protein domains based on the Hydrophobic Cluster Analysis of proteins.
    Bioinformatics, 2015.
  • Tristan Bitard-Feildel, Carsten Kemena, Jennifer Greenwood, Erich Bornberg-Bauer.
    Domain based orthology detection
    BMC Bioinformatic, 2015.
  • Tristan Bitard-Feildel, Magdalena Heberlein, Erich Bornberg-Bauer*, Isabelle Callebaut*.
    Detection of Orphan Domains in Drosophila using "Hydrophobic Clustering Analysis"
    Biochimie, 2015.
  • Carsten Kemena, Tristan Bitard Feildel and Erich Bornberg-Bauer.
    MDAT- Aligning multiple domain arrangements.
    BMC Bioinformatics, 2015


  • Tristan Bitard-Feildel, Steffen Klasberg, Magdalena Heberlein, Isabelle Callebaut, Erich Bornberg-Bauer.
    Detection and Evolution of orphan protein domains.
    Talk - SMBE 2015.
  • Tristan Bitard-Feildel, Antoine Vigneron, Jean-François Gibrat.
    Density based clustering algorithms for near native protein conformation search..
    Talk - Miage Seminar 2011.
  • Tristan Bitard-Feildel, Antoine Vigneron, Jean-François Gibrat.
    Ab initio prediction of protein structures.
    Poster - JOBIM 2011.
  • Tristan Bitard-Feildel, Antoine Vigneron, Jean-François Gibrat.
    Heterogeneous coarse-grained model for protein structure predictions.
    Poster - GGMM 2011.
  • Tristan Bitard-Feildel, Antoine Vigneron, Jean-François Gibrat.
    Statistical potential and coarse-grained model for protein structure predictions.
    Poster - JOBIM 2010.

Research and Teaching Experience

Research Experience

  • 2013-now: Post-doctoral Research. WWU Münster, Germany
  • 2009-2012: Doctoral Research. INRA Jouy-enJosas, France
  • 2009 (6 month): Internship, IRISA Rennes, France.
  • 2007 (5 month): Internship, INRIA Montpellier, France.

Student Supervision

  • 2015 (3 month): Forschungsmodul - Lukas Kremer.
    Protein domains analyze in Mammalian orthologous proteins
  • 2015 (on going): PhD student - Steffen Klasberg (unofficial supervision).
    Protein domains emergence and evolution linked to innovation in Arthropoda.
  • 2014 (2+3 month): Forschungsmodul+BSc - Lukas Kremer.
    Protein domains and RNA-seq analyses of the Human and Oposum species.
  • 2013 (2 month): Forschungsmodul - Lukas Vaut.
    Evolution of the Protein Domain Universe Graph (PDUG) in different lineages.

Teaching Experience

  • 20{14,15}: Coordination of the MSc module Biocomputing for beginner and advanced student in Python.
    WWU Münster, Germany.
  • 20{13,14,15}: Contribution to the BSc module Bioinformatik II.
    WWU Münster, Germany.
  • 2013: Contribution to the MSc module Computational and statistical sequence analysis.
    WWU Münster, Germany.
  • 2011: Coordination of the course Introduction to Python during the Migale platform training days.
    Public : researchers in biology without programming background
    MIG INRA, Jouy-en-Josas.
  • 2010: Contribution to the BSc module Learning C programming (biology).
    University of Evry, France
  • 2010: Coordination of the BSc module Algorithmic in C (mathematics/computer science).
    University of Evry, France
  • 2010: Contribution to the BSc module Java for biocomputing.
    University of Evry, France


  • 2009-2012: PhD, Ab initio prediction of protein structures
    Antoine Vigneron, Jean-François Gibrat. INRA MIG Jouy-en-Josas (Paris area), France.
  • 2007-2009: Master of Science in Biological System Modelling.
    University of Rennes 1, Rennes, France.
  • 2004-2007: Bachelor of Science in Biology (minor Computer Science).
    University of Rennes 1, Rennes, France.